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Title: 頻尿・尿失禁に対する塩酸テロジリンの臨床評価
Other Titles: Clinical evaluation of terodiline hydrochloride in patients with urinary frequency or incontinence
Authors: 安野, 博彦  KAKEN_name
小川, 隆義  KAKEN_name
荒川, 創一  KAKEN_name
松本, 修  KAKEN_name
守殿, 貞夫  KAKEN_name
梅津, 敬一  KAKEN_name
山下, 真寿男  KAKEN_name
仙石, 淳  KAKEN_name
広岡, 九兵衛  KAKEN_name
島谷, 昇  KAKEN_name
井上, 隆朗  KAKEN_name
田中, 宏和  KAKEN_name
大部, 亨  KAKEN_name
吉村, 光司  KAKEN_name
岡田, 弘  KAKEN_name
源吉, 顕治  KAKEN_name
片岡, 頒雄  KAKEN_name
松下, 全巳  KAKEN_name
稲葉, 洋子  KAKEN_name
泉, 武寛  KAKEN_name
山田, 裕二  KAKEN_name
岡田, 泰長  KAKEN_name
川井田, 徳之  KAKEN_name
杉本, 正行  KAKEN_name
富岡, 収  KAKEN_name
藤井, 明  KAKEN_name
桑山, 雅行  KAKEN_name
山中, 望  KAKEN_name
藤沢, 正人  KAKEN_name
原田, 益善  KAKEN_name
柯, 昭仁  KAKEN_name
羽間, 稔  KAKEN_name
北野, 喜彦  KAKEN_name
小田, 芳経  KAKEN_name
田, 珠相  KAKEN_name
Author's alias: Yasuno, Hirohiko
Ogawa, Takayoshi
Arakawa, Soichi
Matsumoto, Osamu
Kamidono, Sadao
Umezu, Keiichi
Yamashita, Masuo
Sengoku, Atsushi
Hirooka, Kuhei
Shimatani, Noboru
Inoue, Takaaki
Tanaka, Hirokazu
Obe, Toru
Yoshimura, Mitsushi
Okada, Hiroshi
Minayoshi, Kenji
Kataoka, Nobuo
Matsushita, Masami
Inaba, Yoko
Izumi, Takehiro
Yamada, Yuji
Okada, Yasunaga
Kawaida, Noriyuki
Sugimoto, Masayuki
Tomioka, Osamu
Fujii, Akira
Kuwayama, Masayuki
Yamanaka, Nozomu
Fujisawa, Masato
Hrada, Masuyoshi
Ka, Akihito
Hazama, Minoru
Kitano, Yoshihiko
Oda, Yoshinori
Den, Juso
Keywords: Terodiline hydrochloride
Clinical effect
Urinary frequency
Urinary incontinence
Detrusor instability
Issue Date: Apr-1991
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 37
Issue: 4
Start page: 431
End page: 439
Abstract: Detrusor instabilityに基づく頻尿・尿失禁患者99例(うち安全性のみ対象例3例を含む)を対象に,塩酸テロジリン1日24 mg, 4週間経口投与した.1)最終全般改善率は88.5%であった.2)自覚症状の改善率は昼間頻尿66.2%,夜間頻尿68.0%,尿失禁68.8%,夜間遺尿78.3%であった.3)投与前後の平均1日排尿回数は昼間で14.0回から9.8回へ,夜間で4.1回から2.6回へ,平均尿失禁回数は4.4回から1.1回へと有意に減少した.4)残尿10 ml未満と残尿10 ml以上100 ml未満の2群間において,症状別改善率に有意差を認めず,両群ともに良好な成績が得られた.5)副作用は10例にみられたが,うち8例は口渇であり重篤なものはなかった.6)有用性は88.5%であった
A clinical trial with the collaboration of 15 department of urology was performed to determine the usefulness of terodiline hydrochloride in 99 patients whose chief complaints were of pollakisuria or incontinence due to neurogenic bladder, psychogenic disease or chronic cystitis. The patients were orally given 24 mg once daily for 4 weeks. The final global improvement rate was 88.5% and the effective rates on subjective symptoms were; 66.2% for diurnal urinary frequency, 68.0% for nocturnal urinary frequency, 68.8% for urinary incontinence and 78.3% for nocturnal enuresis. Even for the cases having mild bladder outlet obstructive disease, the clinical effective rates were good. Mild side effects were observed in 10 patients, which were dry mouth and others. The results obtained from this trial suggest that terodiline hydrochloride may be useful for the treatment of urinary frequency and incontinence caused by detrusor instability.
URI: http://hdl.handle.net/2433/117150
PubMed ID: 1892003
Appears in Collections:Vol.37 No.4

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