Access count of this item: 165

Files in This Item:
File Description SizeFormat 
39_1227.pdf7.19 MBAdobe PDFView/Open
Title: Bisbenzylisoquinolineによる腎癌の多剤耐性の克服
Other Titles: Circumvention of the multidrug-resistance in renal cancer by bisbenzylisoquinoline
Authors: 筧, 善行  KAKEN_name
橋村, 孝幸  KAKEN_name
吉田, 修  KAKEN_name
清川, 岳彦  KAKEN_name
兼松, 明弘  KAKEN_name
Author's alias: Kakehi, Yoshiyuki
Hashimura, Takayuki
Yoshida, Osamu
Segawa, Takehiko
Kanematsu, Akihiro
Keywords: MDR
Renal cell carcinoma
Bisbenzylisoquinoline
Issue Date: Dec-1993
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 39
Issue: 12
Start page: 1227
End page: 1232
Abstract: A bisbenzylisoquinoline alkaloid, cepharanthine, significantly enhanced vinblastine, adriamycin and etoposide sensitivities in P-glycoprotein positive renal cancer cells. However, it did not show any enhancing effect on cisplatin sensitivity. Four patients with metastatic renal cell carcinomas were treated with intraarterial chemotherapy using vinblastine and/or adriamycin in combination with cepharanthine for their metastatic lesions (3 bone and 1 contralateral kidney metastases). A partial response was observed in 1 patient with femoral bone metastasis and a minor response in 1 patient with lumbar bone metastasis, although they were also treated with interferons. No adverse effects associated with cepharanthine were seen except in one patient complaining of redness and burning sense of the skin probably due to its vaso-dilatation effect.
URI: http://hdl.handle.net/2433/117996
PubMed ID: 8285174
Appears in Collections:Vol.39 No.12

Show full item record

Export to RefWorks


Export Format: 


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.