Mitomycin C, Cytosine arabinoside併用による膀胱腫瘍の腔内注入療法の成績と意義

Abstract

37例の膀胱腫瘍に対しMMC 20 mg+CA 200 mg/30 ml salineの注入療法を行ない, 平均13.5回の注入りより18例において, 内視鏡的にあるいは組織学的に腫瘍の消失をみた.腫瘍の性状でみると, 小さな, low grade, low stage, 表面がvillousな腫瘍でより高い有効率を示した.また注入治療が有効であった症例は, 無効であった場合に比し膀胱内再発頻度が著明に減少した

The anti-tumor effect of twice a week instillation of 30 mg mitomycin C combined with 200 mg cytosine arabinoside dissolved in 30 ml saline was studied in 37 bladder tumor patients. Endoscopic or histological disappearance of the tumor was observed in 19 cases, average instillation being 16.4 times. Small (less than 1 cm in diameter), low grade, low stage and villous-surfaced tumors were more sensitive to this therapy. Further more, in the cases showing a complete response, frequency of the intravesical tumor recurrence significantly decreased compared with the cases showing no response. The clinical results of this therapy are compared mainly with those of TUR performed at our hospital, and the usefulness and clinical limitation of this kind of management in the treatment of bladder tumors are discussed.