腎細胞癌の臨床病理学的検討 "特に組織像と臨床検査所見との関係について"

Abstract

過去17年間にTEKKグループにおいて腎摘出術がおこなわれ組織学的に確認された128例の腎細胞癌患者の組織像と臨床所見との関連について検討した.1) Gradeが高くなるほど赤沈亢進症例, CRP陽性症例が有意に増加していた.2) α2-globulin上昇症例は, Grade 1, Grade 2に比べGrade 3では有意に増加していた.3) Spindle cell型では, 8例中7例において赤沈亢進, CRP陽性, α2-globulin上昇がみられた.4)境界不鮮明例では, 境界鮮明例に比べ赤沈亢進, CRP陽性が増加していたが有意の差はみられなかった.5) Gradeが高くなるほどquick typeの占める割合が有意に高かった.Spindle cell型では8例中7例がquick typeであった.境界不鮮明例では, 境界鮮明例に比べquick typeが有意に多くみられた

The relationship between the histological and clinical findings of 128 cases of renal cell carcinoma operated on during the past 17 years were analyzed. With elevation of tumor grading, the elevated ESR and CRP-positive cases were increased with a significant difference. The serum alpha 2-globulin was elevated in the grade 3 group significantly, but not in the grade 1 or 2 group. Seven of the eight spindle cell type cases showed an elevation of ESR, CRP-positive and an elevation of alpha 2-globulin. There was no difference in clinical findings between well circumscribed border and poorly demarcated margin. A high percentage of quick type cases of renal cell carcinoma were found in high grade cases with a significant difference.