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Title: 複雑性尿路感染症に対するFortimicinとCefotax併用療法の臨床的評価
Other Titles: Clinical evaluation of combination therapy with Fortimicin and Cefotax in the treatment of complicated urinary tract infections
Authors: 坂下, 茂夫  KAKEN_name
浅野, 嘉文  KAKEN_name
富樫, 正樹  KAKEN_name
丸, 彰夫  KAKEN_name
小柳, 知彦  KAKEN_name
葛西, 津世志  KAKEN_name
波治, 武美  KAKEN_name
三橋, 公英  KAKEN_name
網野, 勇  KAKEN_name
兼田, 達夫  KAKEN_name
南, 茂正  KAKEN_name
西田, 亨  KAKEN_name
草階, 佑幸  KAKEN_name
大橋, 伸生  KAKEN_name
山田, 智二  KAKEN_name
平野, 哲夫  KAKEN_name
松野, 正  KAKEN_name
大塚, 晃  KAKEN_name
川倉, 宏一  KAKEN_name
藤枝, 順一郎  KAKEN_name
大室, 博  KAKEN_name
伊藤, 勇市  KAKEN_name
久島, 貞一  KAKEN_name
中西, 正一郎  KAKEN_name
高松, 恒夫  KAKEN_name
寺島, 光行  KAKEN_name
熊谷, 章  KAKEN_name
Author's alias: Sakashita, Shigeo
Asano, Yoshifumi
Togashi, Masaki
Maru, Akio
Koyanagi, Tomohiko
Kasai, Tsuyoshi
Namiji, Takemi
Mitsuhashi, Kimiyoshi
Amino, Isamu
Kaneta, Tatsuo
Minami, Shigemasa
Nishida, Toru
Kusakai, Hiroyuki
Ohashi, Nobuo
Yamada, Tomoji
Hirano, Tetsuo
Matsuno, Tadashi
Otsuka, Akira
Kawakura, Koichi
Fujieda, Junichiro
Omuro, Hiroshi
Ito, Yuichi
Hisajima, Sadakazu
Nakanishi, Syoichiro
Takamatsu, Tsuneo
Terashima, Mitsuyuki
Kumagai, Akira
Keywords: Adolescent
Adult
Aged
Aged, 80 and over
Aminoglycosides
Anti-Bacterial Agents/administration & dosage/therapeutic use
Bacteria/isolation & purification
Cefotaxime/administration & dosage/therapeutic use
Clinical Trials as Topic
Drug Therapy, Combination
Female
Humans
Injections, Intramuscular
Injections, Intravenous
Male
Middle Aged
Urinary Tract Infections/drug therapy/microbiology
Issue Date: Oct-1987
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 33
Issue: 10
Start page: 1718
End page: 1723
Abstract: 63例の複雑性尿路感染症患者に対してFortimicin(R) 400 mg/日,Cefotax(R) 2 g/日の5日間の併用療法を行い,臨床的効果を評価した.1)単独感染例は52例であり,このうち30例はカテーテル留置症例であった.混合感染例は11例であり,うち10例はカテーテル留置例であった.2) Fortimicin(R)とCefotax(R)の併用療法の総合有効率は単独感染例で67.3%で,混合感染例で72.7%であり,全症例の有効率は68.3%であった.3)分離された尿中細菌株76株のうちおもな細菌はE. coli 15株,Ps. aeruginosa 13株,S. marcescens 12株であり,それぞれの菌消失率は100%,38.5%,83.3%であった.4) Fortimicin(R)とCefotax(R)の併用療法による重篤な副作用や血液検査所見の異常はみられなかった
Clinical efficacy of combination therapy using Fortimicin (ASTM) and Cefotax (CTX) was studied in 63 patients with complicated urinary tract infections. The patients received 200 mg of ASTM i.m. and 1 g of CTX i.v. twice a day. The overall clinical efficacy of the treatment was evaluated by criteria proposed by the Japanese UTI Committee. The overall clinical efficacy rate was 68.3%. The rate was 67.3% in the patients with single bacterial infection and 72.7% in those with mixed infections. Subjective side effects were observed in one of the patients. Drug related aggravation in laboratory tests was observed in 8 items in 8 patients, but these were mild changes. We concluded that combination therapy with ASTM and CTX was useful for the treatment of complicated urinary tract infections.
URI: http://hdl.handle.net/2433/119292
PubMed ID: 3328504
Appears in Collections:Vol.33 No.10

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