男性不妊と亜鉛に関する基礎的研究

Abstract

1)精漿中蛋白非結合亜鉛(限外濾過性亜鉛)と精子運動能との間に正の相関関係があった.2)蛋白非結合亜鉛として低分子物質結合亜鉛を精製し, ゲルクロマトグラフィーおよびgas chromatography/mass spectrometryによって本物質はクエン酸亜鉛であることを証明した.3)精子無力症患者精液にクエン酸亜鉛を添加することにより, 精子運動能が改善された

The physiological role of zinc in sperm motility was studied. There was a positive correlation between the sperm motility and the low molecular weight binding zinc (ultrafiltrable zinc) concentration. The low molecular weight binding zinc was purified by gel filtration and identified as zinc citrate by gas chromatography/mass spectrometry. The addition of zinc citrate to the fresh semen of the patients with asthenozoospermia stimulated sperm motility. These results suggest that zinc has a significant role in human sperm motility.