Cefpiramide(CPM)の前立腺組織内移行に関する検討

Abstract

12例の前立腺肥大症患者を対象とし, CPM 1.0 gの静脈内投与を行い, 血清内濃度および恥骨後式前立腺摘除術にて採取した前立腺組織内への移行を検討した.CPMの組織内濃度は, グラム陰性菌のみならずグラム陽性菌に対しても, その抗菌作用が期待できる値を示した

The concentration of CPM in prostatic tissue and serum in 12 patients with benign prostatic hypertrophy was measured. One gram of CPM was injected intravenously prior to prostatectomy. One, 2, 3 and 5 hours following the administration of CPM, the mean serum level of CPM was 142, 88.2, 87.4 and 61.2 micrograms/ml, respectively, while the mean level in the prostatic tissue was 48.3, 15.1, 15.6 and 8.3 micrograms/g, respectively. The prostatic tissue level of CPM was thought to be enough to eradicate gram-negative and gram-positive bacteria in the prostate. It is presumed from our study that clinical effectiveness of CPM might be expected in the case of acute or chronic bacterial prostatitis.