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タイトル: | ピリドンカルボン酸合成抗菌剤の前立腺組織移行について |
その他のタイトル: | Comparison of enoxacin, ofloxacin, and norfloxacin concentration in human benign prostatic tissue |
著者: | 安本, 亮二 浅川, 正純 |
著者名の別形: | YASUMOTO, Ryoji ASAKAWA, Masazumi |
キーワード: | Enoxacin Ofloxacin Norfloxacin Prostatic concentration |
発行日: | Aug-1988 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 34 |
号: | 8 |
開始ページ: | 1519 |
終了ページ: | 1521 |
抄録: | The penetration of pyridone-carboxylic acid drugs into benign prostatic tissue was examined. Twenty-nine patients were studied; 11 for ofloxacin (OFLX) 10 for enoxacin (ENX); and 8 for norfloxacin (NFLX). These drugs were administered orally at a dose of 200 mg three times one day before and twice on the day of operation. Blood sample was taken 30 min before operation and prostatic tissue sample was taken during operation. The mean prostatic concentration of ENX, OFLX and NFLX was 5.81 +/- 2.95 micrograms/g (range 2.99-7.92), 5.51 +/- 1.79 (3.62-7.19), and 4.42 +/- 1.94 (2.45-7.76), respectively. The mean serum concentration of ENX, OFLX and NFLX was 4.87 +/- 1.39 micrograms/ml (3.13-7.44), 5.36 +/- 1.28 (3.12-8.24), and 2.89 +/- 2.34 (0.87-8.33), respectively. The mean ratio of prostatic concentration/serum concentration of ENX, OFLX and NFLX was 1.21 +/- 0.63 (0.82-3.00), 1.06 +/- 0.31, (0.55-1.54) and 2.06 +/- 1.36 (0.93-4.26), respectively. Our findings suggested that the drugs ENX, OFLX and NFLX are useful for prostatic diseases, especially prostatitis. |
URI: | http://hdl.handle.net/2433/119655 |
PubMed ID: | 3195414 |
出現コレクション: | Vol.34 No.8 |
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