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タイトル: | 男子不妊症患者の精巣生検組織像と造精機能評価 |
その他のタイトル: | Analysis of histological findings of testicular biopsies in male infertility |
著者: | 山口, 安三 大田原, 佳久 田島, 惇 阿曽, 佳郎 |
著者名の別形: | YAMAGUCHI, Yasuzo OTAWARA, Yoshihisa TAJIMA, Atsushi ASO, Yoshio |
キーワード: | Idiopathic male infertility Testicular biopsy Immunohistochemical localization ABC (avidin-biotin complex) method |
発行日: | Nov-1988 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 34 |
号: | 11 |
開始ページ: | 1953 |
終了ページ: | 1957 |
抄録: | Histological findings of testicular biopsy were studied following the Johnsen's score count method in 68 cases of idiopathic male infertility, and the relation between serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), and testosterone (T) and histological findings were analyzed in the same cases. In oligozoospermia, there were no cases showing a Johnsen's score lower than 4. The score counts ranged widely from 1 to 9 in azoospermia. The cases with the Johnsen's score count lower than 4 revealed high values of serum LH and FSH and a low level of serum T. There was no relationship between Leydig cell accumulations or thickness of the seminiferous tubular walls and score values. Further examination using ABC (avidin biotin complex) method was carried out to find the localization of FSH and T in the testicular tissues. Immunohistochemical localization FSH was not noted in normal testicular tissues obtained the autopsy cases and testicular biopsy specimens of idiopathic male infertility. The localization of T was found in the Leydig cells and the Sertoli cells of normal and infertile testes. In the cases with the thickness of tubular walls, Sertoli cells were not stained. This fact might indicate that absence of T in Sertoli cells is related to spermatogenetic maturation only with the thickness of seminiferous tubular walls. |
URI: | http://hdl.handle.net/2433/119771 |
PubMed ID: | 3149450 |
出現コレクション: | Vol.34 No.11 |
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