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タイトル: | 精子形成障害の内分泌学的背景 - ライディヒおよびセルトリ細胞機能のin vivoおよびin vitroでの評価 - |
その他のタイトル: | Endocrinological profile of human spermatogenic impairment--evaluation of function of Leydig and Sertoli cells in vivo or in vitro studies |
著者: | 奥山, 明彦 野々村, 祝夫 中村, 正広 並木, 幹夫 松田, 稔 土井, 康裕 松井, 孝之 高, 栄哲 近藤, 宣幸 竹山, 政美 藤岡, 秀樹 |
著者名の別形: | OKUYAMA, Akihiko NONOMURA, Norio NAKAMURA, Masahiro NAMIKI, Mikio MATSUDA, Minoru DOI, Yasuhiro MATSUI, Takayuki KOH, Eitetsu KONDOH, Nobuyuki TAKEYAMA, Masami FUJIOKA, Hideki |
キーワード: | Spermatogenic impairment Endocrinology Leydig cell Sertoli cell |
発行日: | Nov-1988 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 34 |
号: | 11 |
開始ページ: | 1943 |
終了ページ: | 1948 |
抄録: | In vivo and in vitro studies were performed to determine the function of Leydig and Sertoli cells of the human testis with various degrees of spermatogenic impairment. The increases in basal and peak serum levels of luteinizing hormone (LH) and follicle stimulating hormone (FSH) after LH-RH administration correlated with the degree of impairment of spermatogenesis, and the basal peripheral blood levels of testosterone and that after human chorionic gonadotropin (hCG) administration for patients with moderate or severe impairment were significantly lower than the values for those with mild impairment. The concentration of testosterone in the internal spermatic vein of varicocele patients with or without hCG treatment did not differ between in mild and moderate impairment. In studies on cultured Sertoli cells, the production rate of plasminogen activator in patients with severe impairment was significantly lower than that in patients with moderate or mild impairment. The decrease in testicular high-affinity binding site for FSH correlated with the degree of hypospermatogenesis found in idiopathic male infertility, but, on the contrary, the hCG (LH) receptors showed no correlation with the degree of impairment of spermatogenesis. In the investigation of the relationship between testicular FSH receptors and the effectiveness of human menopausal gonadotropin (hMG)-hCG treatment on idiopathic male infertility, the presence or absence of testicular FSH receptors predicted the responsiveness to the treatment. |
URI: | http://hdl.handle.net/2433/119773 |
PubMed ID: | 3149448 |
出現コレクション: | Vol.34 No.11 |
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