Ubretidの神経因性膀胱に対する効果および血清β-Glucuronidaseにおよぼす影響

Abstract

Clinical effects of Ubretid on neurogenic bladder dysfunction were evaluated by cystoadaptometry. Oral administration of Ubretid 5 mg daily for 3 weeks made the hypotonic and the hypertonic bladders to be normotonic in several cases. This is the noteworthy merit of Ubretid distinguished from bethanechol chloride, which could not alter the hypertonic bladder toward normotonic. In many traumatic paraplegics (30 in 49), the serum p-glucuronidase activities were high, over 300 pgjdljhr. This finding was considered as a sign suggesting of abnormal sugar metabolism in this disorders. By oral administration of Ubretid 5 mg daily for a week the high serum p-glucuronidase activities in traumatic paraplegics were reduced to normal in many cases (7 in 12). Diagnostic value of high serum p-glucuronidase in traumatic paraplegics, and therapeutic value to reduce the high serum p-glucuronidase to normal were still entirely unknown.