前立腺肥大症に対するPPCの使用経験

Abstract

The palliative treatment of prostatic hypertrophy with PPC* has been reported by Feinblatt and Gant (1958), Damrau (1962), Shiga et al. (1968) and Yamanouchi et al. (1968). Our special attention was directed to clinical value of PPC, and PPC was t ried on 32 cases diagnosed as benign prostatic hypertrophy. For diagnosis and evaluation of the effect, rectal examination, urethrocystogram and cystoscopy were performed besides the routine clinical examinations. In addition, the flow meter examination was done for some of the cases. The effect of PPC oral adm i n istration was as follows : (1) Effect on the improvement of subjective symptom s Urinary frequency7reduced : 77.7 % Nocturia relieved : 68.4 % Difficulty on urination re l i e v ed : 77.3 % Feeling of residual urine relieved : 7 1 . 4 % (2) Effect on the improvement of objective s y mptom Volume of residual urine reduced (comp l e t e l y) : 80.0 % (3) Effectiveness of PPC with flow meter examination was observed in some cases. (4) Side effect was observed only in one case and was relieved with the adm i n istration of a gastrointestinal drug. * PPC is prepared in a capsule containing 410 mg of a mixture of glycine (amino acetic acid), L-alanine and L-glutamic acid.