尿路結石症の発生原因に関する研究 尿中蓚酸量に対するVitamin B6およびB1の影響について

Abstract

Oxalic acid metabolism is of considerable importance, because approximately 70% of human urinary stones are composed of either pure calcium oxalate or calcium oxalate plus apatite. It is well known that vitamin B6 affects oxalic acid metabolism in vivo and vitamin B1 does it in vitro. However, the effect of vitamin B1 on urinary oxalate excretion has not been established yet. In this paper, the influence of vitamin B1 deficiency on urinary oxalate excretion in rats was studied and was compared with the change in vitamin B6 deficiency and in both vitamin B6 and B1 deficiency. The oxalic acid in urine was estimated by Zarembski and Hodgkinson's method. In vitamin B1 deficient rats, the increase of urinary oxalate excretion was proved. However, the increase was moderate in comparison with the marked increase of urinary oxalate excretion in vitamin B6 deficient rats. There was no difference between the increase in vitamin B6 deficient rats and the increase in both vitamin B6 and B1 deficient rats. Patients with oxalate-containing urinary stone excreted approximately normal amounts of oxalate except several cases with increased urinary oxalate excretion. In these stone patients with increased urinary oxalate excretion, vitamin B6 and vitamin B1 administration reduced the urinary oxalate excretion. From these results, it is suggested that vitamin B6 and B1 play a significant role in oxalate metabolism and the etiology of oxalate-containing urinary stone.