尿路感染症に対するCephalexinの応用

Abstract

1) Clinical results. CEPHALEXIN (CEX) was orally administered to fifty cases of urinary tract infection. Clinical result was as follows: excellent 35, fair 7 and non-effective 8. The effectiveness was, therefore, estimated to be 84%. 2) Blood levels. The highest blood level after single administration of 0.5 or 1.0 gram of CEX was observed at one hour. Then, the blood level fell rapidly, although the effective level continued to four hours. 3) Urinary excretion. Eighty percent of CEX of 1.0 g in a single dosage was proved to be excreted in urine in six hours. 4) Antimicrobial potency. Approximately 1/2 to 1/4 of antimicrobial potency of CER was observed against Staphylococcus, E. coli, Proteus and Klebsiella. 5) Side effects. No side effect worthy to mention was observed.