膀胱炎症例における化学療法剤とTanderilの併用効果について

Abstract

The subjects consisted of 29 patients with acute non-specific cystitis and 27 with chronic non-specific cystitis. Disc sensitivity test was performed to select a chemotherapeutic having a high activity against bacteria. This chemotherapeutic and Tanderil 600 mg/day were concomitantly administered to the patients for 14 consecutive days. Clinical effectiveness of these agents given in combination was appraised 7 and 14 days respectively after administration, based on symptomatic changes, urinary findings and cystoscopy. Control groups consisted of 8 patients with acute non-specific cystitis and 8 with chronic non-specific cystitis, who were also subjected to the disc sensitivity test. Thereafter, the most highly sensitive chemotherapeutic alone was given to these patients for 14 consecutive days, and the effectiveness of the drug was appraised in a similar fashion as in the patients receiving a combination of chemotherapeutic and Tanderil. The results of comparative studies between both groups are as given below. 1) Acute non-specific cystitis: No differences were observed between both groups in the results obtained, i. e. most of the patients showed symptomatic recovery within 2 weeks. 2) Chronic non-specific cystitis: Symptomatic recovery was marked in the chemotherapeutic plus Tanderil treated group than in the control group. 3) Side effects were encountered in 12 patients, but were not so severe as necessitating discontinuance of medication. However, in view of possible incidence of edema, medication should be avoided in such patients as having renal dysfunction. It may be concluded from these results that a combined therapy with an effective chemotherapeutic against. these pathogenic organisms and Tanderil is recommendable in patients with cystitis, especially chronic one.