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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| 15_0744.pdf | 231.5 kB | Adobe PDF | 見る/開く |
| タイトル: | 尿路感染症に対するAC-PCの応用 --基礎的および臨床的研究-- |
| その他のタイトル: | Study on AC-PC against urinary tract infection--fundamental and clinical investigation |
| 著者: | 大越, 正秋  名出, 頼男 川村, 猛 川上, 隆 鈴木, 恵三 長久保, 一朗 |
| 著者名の別形: | Okoshi, Masaki Naide, Yorio Kawamura, Takeshi Kawakami, Takashi Suzuki, Keizo Nagakubo, Ichiro |
| キーワード: | Cystitis/drug therapy Humans Microbial Sensitivity Tests Penicillins/adverse effects/metabolism/therapeutic use Urethritis/drug therapy Urinary Tract Infections/drug therapy |
| 発行日: | Oct-1969 |
| 出版者: | 京都大学医学部泌尿器科学教室 |
| 誌名: | 泌尿器科紀要 |
| 巻: | 15 |
| 号: | 10 |
| 開始ページ: | 744 |
| 終了ページ: | 747 |
| 抄録: | Evaluation of AC-PC or 6-(aminocyclohexane carboxamide) penicillanic acid has been done in the laboratory and clinically. By oral administration of single dose of 250 mg, peak blood level of 10 γ/ml was attained at 30 minutes after administration which showed rapid absorption of the drug in the alimentary tract. About 40 % of the amount taken was excreted in urine within 2 hours with peak level of 2, 000 γ/ml. Minimal inhibitory concentration of AC-PC was much higher against Gram-negative rod bacteria than that of ampicillin or carbenicillin. However, AC-PC has been effective in the treatment of primary acute infections of the urinary tract. The pathogens were mostly E. coli strains. The effectiveness of this drug in the treatment of simple urinary infections might be due to high drug level in urine which exceeds minimal inhibitory concentration against the pathogens. |
| URI: | http://hdl.handle.net/2433/120053 |
| PubMed ID: | 5390816 |
| 出現コレクション: | Vol.15 No.10 |
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