泌尿器科領域におけるAC-PCの応用

Abstract

Basic and clinical studies with AC-PC gave the following results: 1. Antibacterial effects The sensitivity of Staphylococcus to AC-PC was well comparable to ARPC, while against E. coli the antibacterial activity was inferior to that of AB-PC. 2. Blood concentration and urinary excretion rate With 500 or 1, 000 mg of oral administration, the blood concentration reached a peak, being 20.9 γ/ml and 30.7γ/ml, respectively, an hour after the intake, and henceforth the level fell rapidly, though it was measurable at 4 hours. The urinary excretion rate after oral administration was quite high, being 54.4 % of 500 mg in 6 hours. 3. Clinical effects Fifty-three cases of various urinary infection were treated with AC-PC. Twenty-three cases showed remarkable improvement, 21 good and 9 no improvement, giving 83.0 % of curative rate. 4. Side effects Five cases out of 53 complained of gastrointestinal disorder, though it was not so serious to withdraw the medication.