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Title: 尿路感染症に対するナタシリンの使用経験
Other Titles: Clinical evaluation of natacillin for urinary tract infection
Authors: 沢西, 謙次  KAKEN_name
松尾, 光雄  KAKEN_name
土屋, 正孝  KAKEN_name
Author's alias: Sawanishi, Kenji
Matsuo, Mitsuo
Tsuchiya, Masataka
Keywords: Acetone
Drug Hypersensitivity/etiology
Injections, Intravenous
Liver Function Tests
Middle Aged
Penicillins/adverse effects/therapeutic use
Skin Tests
Urinary Tract Infections/drug therapy
Issue Date: Jun-1970
Publisher: 京都大学医学部泌尿器科学教室
Journal title: 泌尿器科紀要
Volume: 16
Issue: 6
Start page: 298
End page: 307
Abstract: Thirty cases of various urinary tract infections were treated with NATACILLIN (Hetacillin-K), a product of acetonation from aminobenzyl penicillin. The drug was administered intravenously 250 to 500mg each time and 1 to 4 times a day. The therapeutic effect was evaluated as follows: good 17, fair 8, non-effective 8 and undetermined 1. The effectiveness rate was therefore calculated as 73.5 % which seemed a relatively satisfactory result. The effect upon liver function, was investigated on GOT, GPT and alkaline phosphatase- and that upon renal function was studied on BUN, NPN and PSP test (15 min). Hemograms were also checked. The above examinations were carried out before, on termination of, and one week after administration. No untoward effects were observed on the liver, kidney, and hemopoietic organs. As side effects, slight vascular pain and nausea on injection were encountered in a small number of cases but only transient. One patient developed allergic shock despite negative skin test. This suggested us that care should be taken in the clinical use of this drug.
PubMed ID: 5465254
Appears in Collections:Vol.16 No.6

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