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ファイル | 記述 | サイズ | フォーマット | |
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16_0429.pdf | 2.52 MB | Adobe PDF | 見る/開く |
タイトル: | ラットの前立腺および精嚢におよぼすgestonorone caproateの影響 |
その他のタイトル: | Effects of gestonorone caproate on prostate and seminal vesicles of the rat |
著者名の別形: | Hahn, J. D. |
キーワード: | Animals Body Weight/drug effects Caproates/pharmacology Histocytochemistry Hydroxyprogesterones/pharmacology Hypophysectomy Injections, Subcutaneous Male Organ Size Pregnanes/pharmacology Progesterone/pharmacology Prostate/drug effects Rats Seminal Vesicles/drug effects Sexual Behavior, Animal/drug effects Testis/cytology/drug effects |
発行日: | Sep-1970 |
出版者: | 京都大学医学部泌尿器科学教室 |
誌名: | 泌尿器科紀要 |
巻: | 16 |
号: | 9 |
開始ページ: | 429 |
終了ページ: | 437 |
抄録: | The effect of long acting gestonorone caproate on the accessory sex glands and on the function, morphology and enzyme histochemistry of the testicle as well as on the libido of adult male rats were investigated. The Weight of the prostate and seminal vesicles following treatment for 6 and 15 weeks was reduced approximately 40-70 %, whereas the weight and the histological and histochemical appearance of the testicles remained unchanged as compared to the controls. An effect on the libido was not observed. A five-week treatment of hypophysectomized male rats supplemented with human chorionic gonadotropic hormone resulted in a reduction in weight of prostate and seminal vesicles of approximately 30 % compared to hypophysectomized control animals supplemented with human chorionic gonadotropic hormone. From these experiments, it is assumed that gestonorone caproate has a direct effect on prostate and seminal vesicles independent of the pituitary gland. The basic mechanism of this effect is unknown at present. |
URI: | http://hdl.handle.net/2433/121170 |
PubMed ID: | 5528737 |
出現コレクション: | Vol.16 No.9 |
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