Cefazolinに関する基礎的ならびに臨床的検討

Abstract

The report deals with the laboratory and clinical assessment of Cefazolin (CEZ) on urinary tract infections. The results obtained were summarized as follows. 1) The MIC of CEZ against 164 strains of the bacteria isolated from secondary urinary tract infections were determined by the plate dilution method. The MIC were less than 12.5 meg/ml in 50% of Staphylococcus aureus, 60% of Staphylococcus epidermidis, 25% of Enterococcus, 45.4% of Klebsiella, 88.5% of E. coli, and only 4.8% of Pseudomonas aeruginosa. 2) Serum concentration following an intramuscular administration of 500 mg in two healthy adults reached the peak level of 32.2mcg/ml in average after one hour. Urinary recovery was 87.9% for 24 hours. 3) Of eight patients with the urinary tract infection secondary to urological surgeries, six were treated effectively by parenteral administration of 1.0 to 2.0 gm a day for 5 to 7 days. 4) No significant changes in blood chemistry were noticed in the patients receiving intravenously total of 10 to 18 gm.