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18_0045.pdf | 1.3 MB | Adobe PDF | 見る/開く |
タイトル: | 前立腺肥大症に対するPolyene Macrolide投与の影響 |
その他のタイトル: | Effect of polyene macrolide administration on prostatic hypertrophy |
著者: | 山本, 忠治郎 身吉, 隆雄 並河, 広二 尾上, 泰彦 |
著者名の別形: | Yamamoto, Chujiro Miyoshi, Takao Namikawa, Koji Onoe, Yasuhiko |
キーワード: | Acid Phosphatase/blood Aged Alanine Transaminase/blood Alkaline Phosphatase/blood Amphotericin B/therapeutic use Aspartate Aminotransferases/blood Blood Proteins/analysis Blood Urea Nitrogen Chlorine/blood Cholesterol/blood Glutamine/blood Humans Male Middle Aged Nitrogen/blood Potassium/blood Prostatic Hyperplasia/drug therapy/pathology Sodium/blood |
発行日: | Jan-1972 |
出版者: | 京都大学医学部泌尿器科学教室 |
誌名: | 泌尿器科紀要 |
巻: | 18 |
号: | 1 |
開始ページ: | 45 |
終了ページ: | 51 |
抄録: | Amphotericin B, one of the polyene macrolide preparations, was administered to 10 cases of prostatic hypertrophy associated with hypertension, cardiac insufficiency or diabetes mellitus in a daily dose of 800~ 1, 200 mg for a period of 2~ 10 weeks. All of these cases were on conservative therapy. The object of the administration was to study the effect of amphotericin B with respect to the reduction of adenoma, improvement of clinical symptoms as well as laboratory results. As a result of the administration, marked reduction of adenoma was observed in one case, moderate reduction in 5 and 3 showed little change in adenoma. Improvement of dysuria and frequency at night was noted in 7 cases, whereas 3 showed little change in the symptoms. Disappearance of residual urine was observed in 4, reduction in 3, and the remaining 3 showed little change in the symptoms. It can be said, consequently, that the administration of amphotericin B produced marked effect in one, effect in 5, moderate effect in one and poor effect in 3. One of 5 cases showing effect was prostatectomied thereafter for histological examination which revealed the sloughing of the glandular epithelium, dilated glandular lumen and granulation-like changes. Atrophy of the glandular structure was not observed. |
URI: | http://hdl.handle.net/2433/121334 |
PubMed ID: | 4112553 |
出現コレクション: | Vol.18 No.1 |
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