Minocyclineにかんする基礎的ならびに臨床的検討

Abstract

This report deals with the laboratory and clinical assessment of minocycline on urinary tract infection. The results obtained were summarized as follows. 1) MIC of minocycline against 254 strains of bacteria which were isolated from urinary tract infection during the late four months period in our clinic, was determined by plate dilution method. This determination revealed that Staphylococcus aureus was more sensitive to minocycline than any other bacteria, and that this MIC was not more than 1.56 mcg/ml in about three fourths and was less than 0.39 mcg/ml in about a half of these cocci. The MIC was less than 12.5mcg/ml in 60.9 % of Staphylococcus epidermidis, in 48.9 % of Enterococcus, in 46.2 % of Klebsiella, in 58.3 % of E. coli, in 14.3 % of Cloaca. It was impossible to find out Pseudomonas aeruginosa and Proteus mirabilis having MIC less than 12.5 mcg/ mg. 2) Cross-resistance between minocycline and TC was estimated on Staphylococcus, E. coli and Enterococcus. The cross-resistance was demonstrated in the case of Staphylococcus aureus, while it was unlikely to be proved in the case of the latter two. 3) Serum concentration following a peroral administration of 200 mg in two healthy adults reached a peak level of 1.7mcg/ml in average four hours later. Urinary recovery was 6.7 % for 24 hours. 4) Of nineteen patients suffering from urinary tract infection, eleven were effectively treated without significant side-reactions hy peroral administration of 200 mg a day for 5 to 7 days.