SH-582投与による尿中ステロイド分画への影響

Abstract

There are few reports describing the metabolism following administration of progestational agents in men. It has so far been reported that SH-582 has no endocrinological activities in the organism, and that the compound may have only a mild influence on the adrenal glands and testis, In an attempt to see the excretory patterns of urinary C-19 and C-21 steroids following SH-582 administration, we performed a simultaneous analysis of those steroids by means of gas chromatography before and 3 days after SH-582 administration in old men, which was compared with that in the control subjects consisting of men and women in youth or prime of life who were supposed to have nothing unusual in their endocrinological activities.