膀胱内圧測定からみたFlavoxate hydrochlorideの臨床薬理学的評価(第2報) -二重盲検法による同時対照試験-

Abstract

Nineteen cases of nervous pollakisuria or female vesicopathy were treated with fiavoxate 600 mg per day or placebo for one week. Cystometry was performed before and after the administration. 1. Administration of flavoxate gave rise to increase of both at minimum and maximum desire to void, particularly that at the minimum desire. 2. Resting intravesical pressure both at the minimum and maximum desire to void did not change significantly. Namely, the pressure curve showed a decline. 3. It was speculated that fiavoxate might have some action on the center controlling desire to void besides its relaxing action on the vesical detrusor. 4. Highly significant correlation was proved between the bladder volume at the minimum desire to void and the vesical capacity. Desire to void seemed to be activated by intravesical pressure rather than by vesical distention.