慢性尿路感染症に対するFosfomycin capsuleの使用経験

Abstract

1) Fosfomycin was administered to 20 patients with chronic urinary tract infection caused by Pseudomonas or Serratia. Clinical effectiveness was remarkable in 6, good in 9, uncertain in 1, and none in 4. Effectiveness rate was thus calculated as 78.95%. 2) MIC for Pseudomonas was 3.13 to 12.5 micrograms/ml in 6 of 7 cases, which was superior to other antibiotics. Exact rneasurement of MIC was impossible and relation between clinical results and MIC was not clarified. As to Serratia, MIG ranged between 0.39 and 3.13 micrograms/ml which was far superior to other antibiotics. Clinical response in this group was also excellent (remarkable in 2 and good in 2). 3) Side effects were seen in 3 patients, 2 of them being very slight diarrhea. Liver function was questionable in .5 cases, one of which quickly returned normal. Anyway, no serious untoward effects were observed attributable to the medication of fosfomycin. 4) None of the antibiotics orally administered ever showed such a good effect for Pseudomonas or Serratia infection, espicially for Serratia. Fosfomycin will be a powerful weapon against hospital acquired infection, present and future.