Prostaglandin F2α誘導体の膀胱尿管の排尿運動に関する実験的研究

Abstract

The urodynamic effect of the derivative of prostaglandin F2α-16-(3-trifluoromethylphenoxy) w-tetranor-trans-⊿2-PGF2α methyl ester-is experimentally studied. Six male adult rabbits were studied through transvenous medication. No marked acceralating effect on ureteral movement was obtained. Neuromusclar effect on the urinary bladder was studied through EMG of the trigone, cystometry and the urethral resistance of the bladder neck. Rhythmical movement of the trigonal muscle increased by the above medication. The resistance of the bladder neck also increased. The beneficial effect of this derivative for the treatment against neurogenic bladder was suggested.