泌尿器悪性腫瘍患者における血清蛋白の変動

Abstract

Using a micro-single radial diffusion method, quantitative studies have been made on the serum proteins of urologic cancer patients (27 renal cell cancers, 12 prostatic cancers, and 11 high stage bladder cancers) and expressed by percentage of those obtained on 98 normal volunteers as 100. Of the 30 proteins studied, 12 (α1AG, α1AT, α1X, Znα2, Cp, Hp, C3PA, C4, C5, C9, Hx, βLp) were elevated and 4 (Pre, Alb, α2HS, Tf) were decreased in the renal cell cancer group. The elevations of C9 and Hp were most prominent. In renal cell cancer with distant metastasis, the Pre, Tf and a2HS were high but showed significant decrease to the normal level in 6 months postoperatively. In addition, there was a significant increase of IgM and of IgG in this metastatic group as compared with the non-metastatic group. In the prostatic cancer group, α1AT, Cp, Hp, C5, C9 and β2III were elevated and Alb, α2M, α2HS and Tf were decreased. The elevations of Cp, C9 and Hp were most remarkable. In the high stage bladder cancer group, α1AT, α1AG, Hp, C3PA and C9 were elevated, and Pre and Tf were decreased. A possible clinical significance of the increase of complement and correlation between low fibrinolytic conditions and increase of α1AT in cancer patients are mainly discussed.