抗菌剤の膀胱壁内移行に関する研究 1. 実験的膀胱炎作成家兎におけるPivmecillinam投与時の膀胱壁内Mecillinam濃度ならびにSerratiopeptidase併用時の影響について

Abstract

1. MPC levels of serum and the urinary bladder wall were determined after oral administration of PMPC in the normal rabbits. MPC levels of serum and bladder wall reached to the peak respectively one hour and two hours after administration of PMPC. 2. MPC levels of the bladder wall were determined following instillation of PMPC into the isolated bladder of the rabbit with or without cystitis. MPC levels in the bladder wall were higher in the cystitis group than in the control group. 3. MPC levels in the bladder wall were determined after oral administration of PMPC with or without Serratiopeptidase in the rabbits with or without cystitis. MPC levels in the bladder wall were higher in the cystitis group than in the non-cystitis group. The raise of levels of MPC was the highest in the cystitis group treated by PMPC and Serratiopeptidase.