膀胱を原発とする転移性陰茎癌の3例と, これに対する術前抗癌剤動注および照射療法の経験

Abstract

Metastatic penile carcinoma is regarded as an uncommon entity in urological practice. Recently we have experienced 3 patients with this entity secondary to transitional cell carcinoma of the urinary bladder at our Department. All patients have undergone total emasculation following combination therapy of arterial infusion of anticancer agent, Pepleomycin, and local external irradiation of 60CO, totaling 30 mg and 1800 rad, respectively. Pathohistological study of resected specimens showed areas of coagulation and/or liquefactive necrosis in neoplastic lesions in both cases I and 2, however there were no neoplastic degenerative changes in case 3, who has lived the shortest among 3 patients after their first visits. All were dead within a year of their first visits to this outpatient clinic in spite of the radical treatment of metastatic lesion. Case I has been alive for approximately 8 months after his first visit, case 2 for approximately 7 months and case 3 for approximately 6 months. We reviewed relevant literature and described characteristic features of metastatic penile carcinoma in addition to our experience in 3 patients with metastatic penile carcinoma in this paper.