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タイトル: | 抗癌剤の経膀胱的吸収に関する研究 -膀胱内注入療法の基礎- 第3報 Adriamycinの膀胱腫瘍組織内濃度 |
その他のタイトル: | STUDIES ON THE ABSORPTION OF ANTICANCER AGENTS THROUGH THE BLADDER - BASIS OF THE INSTILLATION THERAPY - 3.URINARY EXCRETION AND VESICAL TISSUE CONCENTRATION OF THE INSTILLED ADRIAMYCIN IN THE PATIENTS WITH BLADDER CANCER |
著者: | 永田, 一夫 |
著者名の別形: | Nagata, Kazuo |
発行日: | Aug-1980 |
出版者: | 京都大学医学部泌尿器科学教室 |
誌名: | 泌尿器科紀要 |
巻: | 26 |
号: | 8 |
開始ページ: | 983 |
終了ページ: | 988 |
抄録: | The absorption of adriamycin through the human bladder was studied, and following results were obtained : 1. Urinary excretion of the instilled adriamycin. Studies were made concerning 4 cases in which urinary diversion was forced by progressive vesical carcinoma. After the instillation of adriamycin (60 mg/20 ml saline) over a one hour period, blood samples and the urine were collected every hour for 6 hours. The blood concentrations of adriamycin after the instillation were trace. Concerning the amount of adriamycin excreted into the urine of patients with urinary diverstion, 0.41±0.19% was excreted druing 6 hours on average. 2. Tissue concentration of adriamycin in patients with vesical cancer. Eighteen patients with vesical carcinoma were examined. Microscopic examination established a dignosis of trasitional cell carcinoma in 14 cases and anaplastic carcinoma in 4 cases. Adriamycin (60 mg/20 ml saline) was instilled in the bladder. One hour later, the tumors were collected by TUR or cystectomy. The average concentration of adriamycin in the tissues of the bladder carcinoma was 10.3 ± 14.4µg/g. The average concentration of transitional cell carcinoma was 5.3±4.5 µg/g and that of anaplastic carcinoma was 27.1±21.8µg/g. |
URI: | http://hdl.handle.net/2433/122711 |
出現コレクション: | Vol.26 No.8 |
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