猪苓湯の薬理学的研究 (1) ラットにおける利尿作用について

Abstract

Extract and decocta of choreito showed a somewhat similar pattern of urinary excretion in rats loaded with water (10 ml/100g b.w., p.o.). In the doses used in the present study, they showed a diuretic action at low dosage and an anti-diuretic action at high dosage. Polyporus and gelatinum among the compositional crude drugs of choreito affected on urinary excretion. Polyporus promoted it at the used dose, and gelatinum showed a facilitatory effect at low dose and an inhibitory effect at high dose. The decrease of urinary volume by high dose observed in the choreito treated group may be at least partly due to the effect of gelatinum. In the repeated administration of choreito extract, a diuretic action was also found. As seen in the present study, a part of diuretic action of choreito is considered to contribute to passage of ureteral stone as reported by T. Kurita.