尿管結石症患者におけるSCE-1365の分腎的尿中濃度

Abstract

In order to confirm that there is difference between urinary excretions of antibiotics by each kidney differs, concentrations of SCE-1365, a new synthesized cefalosporin, in split urine were measured 30 to 50 minutes following an intravenous bolus injection of 500 mg of SCE-1365 in five patients with unilateral ureteral stone. Urine of affected side was sampled from the ureter above the stone and urine of normal side through transurethrally dwelt catheter during the operation. Urine and plasma samples were examined by agar-well plate method using Proteus mirabilis ATCC 21100 as test organism. The urinary concentrations on the affected side ranged from 202.7 to 4050µg /ml, whereas the concentrations on the normal side from zero to 31.3 µg/ml. Ratios of urinary concentration of affected side to that of the normal side were 6.5 to infinity. Ratios of the urinary concentration to the plasma concentration was 12.3 to 700.9 on the affected side, whereas the ratios was zero to 1.9 on the normal side. In Case 5, two other samples of urine were collected from the affected side 10 and 20 minutes besides 50 minutes following the injection and showed level of zero and 0.4 µg /ml, respectively.