実験的膀胱頚部通過障害 第2報 : 膀胱壁内Acetylcholinesterase活性の検討

Abstract

Activities of total cholinesterase and acetylcholinesterase in the vesical wall were measured biochemically in 26 female dogs. The obstruction was induced by a mild ligation of the proximal urethra in 16 dogs and these dogs were examined on the 7th, 21st, 90th and 180th day following operation. Seven days after operation the values of both enzyme activities were slightly lower than those of control dogs. They were little different from the control values 3 weeks and 3 months after operation. Six months after operation, total cholinesterase activity was significantly higher than that of control dogs and acetylcholinesterase activity considerable higher. According to our study, the sensitivity of the vesical muscle strips to acetylcholine was slightly low in these 6 months dogs. These results may suggest a compensation mechanism of vesical function for the infravesica1 obstruction. Vesical capacity and maximum voiding pressure showed no significant relation with these enzyme activities.