神経因性膀胱症例に対する横紋筋弛緩剤の尿水力学的検査法による効果判定 -横紋筋弛緩剤アフロクァロンについて

Abstract

Afloqualone (6-amino-fluoromethyl-3-0-tolyl-4-(3H)-quinazolinone), a striated muscle relaxant, was administered to eighteen patients with detrusor-external urethral sphincter dyssynergia due to neuropathic disepse. The efficacy of the drug was judged from the objective deta by non-transurethral urodynamic studies such as simultaneous measurement of intra-abdominal pressure, tone of anal sphincter, EMG of anal sphincter, urinary flow rate and voiding volume. As the result of urodynamic deta, 56% of the patient treated with Afloqualone showed improvement in urodynamic parameters. Afloqualone, if used in combination with a-blocking agent or B-stimulant, would be useful for the treatment of the patients with neurogenic bladder dysfunction, particularly with hyperreflexic urethral sphincter and detrusor-external urethral sphincter dyssynergia.