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ファイル | 記述 | サイズ | フォーマット | |
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27_1497.pdf | 1.11 MB | Adobe PDF | 見る/開く |
タイトル: | ヌードマウス移植ヒト前立腺癌に対する3種制癌剤の抗腫瘍効果およびその生体内動態 |
その他のタイトル: | THE TUMOR GROWTH REGRESSIVE EFFECT OF THREE TYPES OF ANTITUMOR DRUG ON HUMAN PROSTATIC CARCINOMA TRANSPLANTED IN NUDE MICE, AND THEIR IN VIVO MOVEMENT |
著者: | 秋元, 成太 坪井, 成美 川村, 直樹 中島, 均 由井, 康雄 吉田, 和弘 西村, 泰司 川井, 博 |
著者名の別形: | Akimoto, Masao Tsuboi, Narumi Kawamura, Naoki Nakajima, Hitoshi Yui, Yasuo Yoshida, Kazuhiro Nishimura, Taiji Kawai, Hiroshi |
発行日: | Dec-1981 |
出版者: | 京都大学医学部泌尿器科学教室 |
誌名: | 泌尿器科紀要 |
巻: | 27 |
号: | 12 |
開始ページ: | 1497 |
終了ページ: | 1504 |
抄録: | The growth regressive effect of NK631, MMC and 5FU on human prostatic carcinoma transplanted in nude mice, and their distribution in the tumor, kidney, and skin and subcutaneous tissue were examined. The results were as follows: (1) NK631 showed the growth regressive effect in 15 mg/kg (2 x/w, i.p.) administered group and distributed in the kidney, tumor and skin and subcutaneous tissue in high concentration. (2) MMC showed the growth regressive effect in 2 mg/kg (1 x/w, i.p.) administered group and distributed in the kidney and tumor in relatively high concentration and in the skin and subcutaneous tissue in low concentration. (3) 5FU showed the growth regressive effect in 30 mg/kg (2 x/w, i.p.) administered group and distributed in the kidney and tumor in high concentration and in the skin and subcutaneous tissue in moderate concentration. (4) In therapeutic experiment of anticancer drug on human tumor transplanted in nude mice, care must be taken at the judgement of the growth regressive effect of the drug which distributes in the skin and subcutaneous tissue in high concentration whenever the tumor was transplanted in subcutaneous tissue. |
URI: | http://hdl.handle.net/2433/123005 |
出現コレクション: | Vol.27 No.12 |
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