二重盲検法による女子急性単純性膀胱炎に対するYamacillinとAmpicillinの臨床的効果

Abstract

Yamacillin was administered to 20 patients with acute cystitis 3 capsules (750 mg) per day t.i.d for 3 days. The clinical efficacy was evaluated according to the UTI Committee Standard of Japan. The control group received amino benzylpenicillin. On the other hand, causative microorganisms were investigated in 92 cases of acute cystitis as well as their sensitivity to amino benzylpenicillin. The following results were obtained. 1) Of 20 patients treated with Yamacillin, 12 showed excellent response, 6 good and 2 none. Of 20 treated with amino benzylpenicillin, 3 showed excellent response, 3 good and 4 none. 2) No untoward effect was observed in both groups. 3) Investigation of the causative microorganisms in acute cystitis yielded 77 E. coli, 7 Staphylococcus sp., 3 Proteus mirabilis, 2 Streptococcus sp., 2 Klebsiella pneumoniae and I Citrobacter dinersus. 4) Twenty of 77 strains of E. coli showed resistance to amino benzylpenicillin. Each one of Staphylococcus, Klebsiella and Citrobacter strains was resistant to aminobenzylpenicillins and others all showed sensitivity greater than two plus. 5) Yamacillin seems to be better than previous aminobenzylpenicillin as to absorption, excretion and side effects. It should be used as the first choice antibiotic for urinary tract infection, of course with care of appearance of resistant strains.