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タイトル: 尿路性器悪性腫瘍に対するcis-Diamminedichloroplatinumの使用経験
その他のタイトル: THERAPEUTIC EXPERIENCE WITH CIS-DIAMMINEDICHLOROPLATINUM (CISPLATIN)FOR PATIENTS WITH UROGENITAL MALIGNANT TUMOR
著者: 浅野, 晴好  KAKEN_name
柳岡, 正範  KAKEN_name
森口, 隆一郎  KAKEN_name
藤田, 民夫  KAKEN_name
名出, 頼男  KAKEN_name
井野, 晶夫  KAKEN_name
平野, 正美  KAKEN_name
置塩, 則彦  KAKEN_name
山越, 剛  KAKEN_name
著者名の別形: Asano, Haruyoshi
Yanaoka, Masanori
Moriguchi, Ryuichiro
Fujita, Tamio
Naide, Yorio
Ino, Akio
Hirano, Masami
Okishio, Norihiko
Yamakoshi, Tsuyoshi
発行日: Feb-1982
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 28
号: 特集号
開始ページ: 111
終了ページ: 118
抄録: Cisplatin was administered to eleven patients bearing urogenital malignancies to evaluate clinical efficacy. (1) In testicular tumor cases combination therapy with cisplatin, bleomycin and vinblastine was very effective resulting in 100% efficacy rate. Effect of this combination regimen was noticed in every tumor of germ cell origin and malignant interstitial cell tumor suggesting wide anti-tumor spectrum of this regimen. (2) Efficacy of cisplatin against prostatic cancer was noticed only in 25% of cases by single administration of this drug. Therefore, combination with anti-androgen therapy or other anti-cancer chemotherapeutics should be considered. (3) Efficacy of single administration of cisplatin was noticed in no case ofuroepithelial tumors. Therefore, radiation therapy and other anti-cancer drugs should be combined to obtain anti-tumor effect against malignancies of uroepithelial origin. (4) Renal toxicity and ototoxicity could be avoided by confluent fluid administration combined with diuretics. Therefore, this drug seemed relatively safe to be administered to any case in this respect. However, administration of this drug to aged patients was hindered by rather severe gastrointestinal symptoms.
URI: http://hdl.handle.net/2433/123215
出現コレクション:Vol.28 特集号

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