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タイトル: | 腎移植: Marginal 症例への対応 - 基礎研究からの今後の展望 (第58回日本泌尿器科学会中部総会(金沢)) |
その他のタイトル: | Kidney Transplantation: How Shall We Deal with Marginal Cases ? - Future Prospects from Basic Research |
著者: | 市丸, 直嗣 矢澤, 浩治 高原, 史郎 |
著者名の別形: | Ichimaru, Naotsugu Yazawa, Koji Takahara, Shiro |
キーワード: | Kidney transplantation Hepatocyte growth factor Carbamylated erythropoietin |
発行日: | Aug-2010 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 56 |
号: | 8 |
開始ページ: | 481 |
終了ページ: | 484 |
抄録: | The research performed at the Department of Urology Osaka University Graduate School of Medicine is overviewed. Renal ischemia-reperfusion (I/R) injury is inevitable in transplantation and is related to longterm graft function. MF-1, a bifunctional hepatocyte growth factor-macrophage stimulating protein chimera, was found to prevent apoptosis. In our study, MF-1 directly guarded cultured proximal tubular epithelial cells from hypoxia-induced necrosis and apoptosis in vitro, and MF-1 treatment ameliorated renal dysfunction by preventing apoptosis in rat I/R injury model. The erythropoietin molecule modified by carbamylation (CEPO) has been identified and was demonstrated to protect several organs without increasing the hemoglobin concentration. The therapeutic effect of CEPO was evaluated using an endothelial tube formation assay, and a rat ischemia-reperfusion injury model. CEPO treatment induced more capillarylike formation than EPO. CEPO-treated kidneys showed minimal tubular apoptosis with increased peritubular capillary endothelial cells. We identified a new therapeutic approach using CEPO to protect the kidney from ischemia-reperfusion injury by promoting angiogenesis. |
著作権等: | 許諾条件により本文は2011-09-01に公開 |
URI: | http://hdl.handle.net/2433/123557 |
PubMed ID: | 20808071 |
出現コレクション: | Vol.56 No.8 |
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