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Title: S-1/CDDP 併用による化学療法が奏効した尿膜管癌の1例
Other Titles: A Case of Urachal Carcinoma Treated with S-1/CDDP Combination Chemotherapy
Authors: 関田, 信之  KAKEN_name
藤村, 正亮  KAKEN_name
新井, 寛子  KAKEN_name
柴田, 直樹  KAKEN_name
西川, 里佳  KAKEN_name
菅野, 勇  KAKEN_name
三上, 和男  KAKEN_name
Author's alias: Sekita, Nobuyuki
Fujimura, Masaaki
Arai, Hiroko
Shibata, Naoki
Nishikawa, Rika
Sugano, Isamu
Mikami, Kazuo
Keywords: Urachal carcinoma,Chemotherapy,S-1,Cisplatin
Issue Date: Aug-2010
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 56
Issue: 8
Start page: 447
End page: 451
Abstract: No established treatment exists for urachal carcinoma,except curative resection,and its prognosis is poor. More than 80% of urachal carcinomas are adenocarcinomas. We report a case of advanced urachal carcinoma treated with S-1 and cisplatin combination (S-1/CDDP) chemotherapy. The patient,a 61-yearold woman,presented with macroscopic hematuria. A tumor was detected on the bladder dome and transurethral resection was performed. Histopathological findings indicated poorly differentiated adenocarcinoma. Serum carcinoembryonic antigen and carbohydrate antigen 19-9 levels were 3.5 ng/ml and 140 U/ml respectively. Magnetic resonance images indicated an extension of this tumor to the retroperioneal space. Metastasis to her right ischium was suspected from bone scintigraphy results. The tumor was diagnosed as stage IVB (Sheldon's category) urachal carcinoma. After one cycle of S-1/CDDP chemotherapy,the size of the tumor on the bladder dome decreased,after which total cystectomy was performed. The surgical margin of the cystectomy specimen was negative for malignant cells,although poorly differentiated adenocarcinoma was still observed in this specimen. The findings of this study indicate that this therapy might be beneficial for treating advanced urachal carcinomas. This is the second report of successful treatment of advanced urachal carcinoma with S-1/CDDP chemotherapy.
Rights: 許諾条件により本文は2011-09-01に公開
PubMed ID: 20808064
Appears in Collections:Vol.56 No.8

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