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ファイル | 記述 | サイズ | フォーマット | |
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j.bmc.2008.09.018.pdf | 356.5 kB | Adobe PDF | 見る/開く |
タイトル: | Identification of minimal sequence for HIV-1 fusion inhibitors. |
著者: | Nishikawa, Hiroki Oishi, Shinya https://orcid.org/0000-0002-2833-2539 (unconfirmed) Fujita, Mizuno Watanabe, Kentaro Tokiwa, Rei Ohno, Hiroaki https://orcid.org/0000-0002-3246-4809 (unconfirmed) Kodama, Eiichi Izumi, Kazuki Kajiwara, Keiko Naitoh, Takeshi Matsuoka, Masao Otaka, Akira Fujii, Nobutaka |
著者名の別形: | 大石, 真也 藤井, 信孝 |
キーワード: | HIV-1 Fusion inhibitor α-Helix Heptad repeat |
発行日: | 15-Oct-2008 |
出版者: | Elsevier BV |
誌名: | Bioorganic & medicinal chemistry |
巻: | 16 |
号: | 20 |
開始ページ: | 9184 |
終了ページ: | 9187 |
抄録: | Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment. Recently, the virus-cell membrane fusion process has been identified as a promising target for the development of novel drugs against these resistant variants. In this study, we identified a 29-residue peptide fusion inhibitor, SC29EK, which shows activity comparable to the previously reported inhibitor SC35EK. Some residues in SC29EK not required for interaction with virus gp41 heptad repeat 1 (HR1) were replaced with a non-proteinogenic amino acid, 2-aminoisobutyric acid (Aib), to stabilize the alpha-helix structure and to provide resistance to peptidases. |
著作権等: | © 2008 Elsevier Ltd |
URI: | http://hdl.handle.net/2433/137210 |
DOI(出版社版): | 10.1016/j.bmc.2008.09.018 |
PubMed ID: | 18819810 |
出現コレクション: | 学術雑誌掲載論文等 |
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