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タイトル: Three-tiered risk stratification model to predict progression in Barrett's esophagus using epigenetic and clinical features.
著者: Sato, Fumiaki
Jin, Zhe
Schulmann, Karsten
Wang, Jean
Greenwald, Bruce D
Ito, Tetsuo
Kan, Takatsugu
Hamilton, James P
Yang, Jian
Paun, Bogdan
David, Stefan
Olaru, Alexandru
Cheng, Yulan
Mori, Yuriko
Abraham, John M
Yfantis, Harris G
Wu, Tsung-Teh
Fredericksen, Mary B
Wang, Kenneth K
Canto, Marcia
Romero, Yvonne
Feng, Ziding
Meltzer, Stephen J
著者名の別形: 佐藤, 史顕
発行日: Apr-2008
出版者: Public Library of Science(PLoS)
誌名: PloS one
巻: 3
号: 4
論文番号: e1890
抄録: Barrett's esophagus predisposes to esophageal adenocarcinoma. However, the value of endoscopic surveillance in Barrett's esophagus has been debated because of the low incidence of esophageal adenocarcinoma in Barrett's esophagus. Moreover, high inter-observer and sampling-dependent variation in the histologic staging of dysplasia make clinical risk assessment problematic. In this study, we developed a 3-tiered risk stratification strategy, based on systematically selected epigenetic and clinical parameters, to improve Barrett's esophagus surveillance efficiency.
著作権等: © 2008 Sato et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/138086
DOI(出版社版): 10.1371/journal.pone.0001890
PubMed ID: 18382671
出現コレクション:学術雑誌掲載論文等

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