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j.biomaterials.2010.01.088.pdf | 572.91 kB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Qi, Zhi | en |
dc.contributor.author | Shen, Yanna | en |
dc.contributor.author | Yanai, Goichi | en |
dc.contributor.author | Yang, Kaichiang | en |
dc.contributor.author | Shirouzu, Yasumasa | en |
dc.contributor.author | Hiura, Akihito | en |
dc.contributor.author | Sumi, Shoichiro | en |
dc.contributor.alternative | 角, 昭一郎 | ja |
dc.date.accessioned | 2011-04-25T01:49:35Z | - |
dc.date.available | 2011-04-25T01:49:35Z | - |
dc.date.issued | 2010-05 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/2433/139506 | - |
dc.description.abstract | Islet transplantation is a method for the treatment of type 1 diabetes mellitus (DM) and has been widely performed around the world. The long-term cryopreservation of islets shows many advantages in the field of islet transplantation. Previous studies have described the development of sheet-type polyvinyl alcohol (PVA) macro-encapsulated islets (MEI) to treat type 1 DM without any immunotherapy. The present study examined their beneficial effects on islet cryopreservation. PVA MEI of Wistar rats were divided into three groups of 1-day, 7-day and 30-day cryopreservation at -80 degrees C. The 30-day group showed a lower recovery rate of the islet number and impaired insulin release in comparison to the 1-day group, whereas no significant differences of the in vitro results were observed between the 1-day and 7-day groups. The MEI transplantation recipient mice in the 1-day and 7-day groups reached normoglycemia for a 4-week observation period, and the recipients in 30-day group also showed a significant decrease followed by a slightly higher non-fasting blood glucose level. These results suggest that the PVA MEI are useful for islet long-term cryopreservation, and that the use of cryopreserved PVA MEI may, therefore, be a promising modality for performing DM therapy. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd. | en |
dc.rights | © 2010 Elsevier Ltd. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Polyvinyl alcohol (PVA) | en |
dc.subject | Macro-encapsulated islets (MEIs) | en |
dc.subject | Islet cryopreservation | en |
dc.subject | Islet transplantation | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | C-Peptide/blood | en |
dc.subject.mesh | Cryopreservation/methods | en |
dc.subject.mesh | Glucose Tolerance Test | en |
dc.subject.mesh | Injections, Intraperitoneal | en |
dc.subject.mesh | Insulin/blood | en |
dc.subject.mesh | Islets of Langerhans/metabolism | en |
dc.subject.mesh | Islets of Langerhans/pathology | en |
dc.subject.mesh | Islets of Langerhans Transplantation | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Mice, Inbred C57BL | en |
dc.subject.mesh | Polyvinyl Alcohol/metabolism | en |
dc.subject.mesh | Rats | en |
dc.subject.mesh | Rats, Wistar | en |
dc.subject.mesh | Transplantation, Heterologous | en |
dc.title | The in vivo performance of polyvinyl alcohol macro-encapsulated islets. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11522637 | - |
dc.identifier.jtitle | Biomaterials | en |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 14 | - |
dc.identifier.spage | 4026 | - |
dc.identifier.epage | 4031 | - |
dc.relation.doi | 10.1016/j.biomaterials.2010.01.088 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20149430 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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