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タイトル: | Regenerative medicine for insulin deficiency: creation of pancreatic islets and bioartificial pancreas. |
著者: | Sumi, Shoichiro |
著者名の別形: | 角, 昭一郎 |
キーワード: | Diabetes mellitus β-cells Pancreas Insulin Islets of Langerhans |
発行日: | Jan-2011 |
出版者: | Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer |
誌名: | Journal of hepato-biliary-pancreatic sciences |
巻: | 18 |
号: | 1 |
開始ページ: | 6 |
終了ページ: | 12 |
抄録: | Recent advances in pancreas organogenesis have greatly improved the understanding of cell lineage from inner cell mass to fully differentiated β-cells. Based upon such knowledge, insulin-producing cells similar to β-cells to a certain extent have been generated from various cell sources including embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, although fully differentiated cells comparable to β-cells are not yet available. The bioartificial pancreas is a therapeutic approach to enable allo- and xenotransplantation of islets without immune suppression. Among several types of bioartificial pancreases (BAPs), micro-encapsulated porcine islets are already in use in clinical trials and may, perhaps, replace islet transplantation in the near future. Some types of bioartificial pancreas such as macro-encapsulation are also useful for keeping transplanted cells enclosed in case retrieval is necessary. Therefore, early clinical applications of artificially generated β-like cells, especially those from ESCs or iPS cells, will be considered in combination with retrievable BAPs. |
著作権等: | The final publication is available at www.springerlink.com この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/141997 |
DOI(出版社版): | 10.1007/s00534-010-0303-3 |
PubMed ID: | 20589399 |
出現コレクション: | 学術雑誌掲載論文等 |
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