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Title: Regenerative medicine for insulin deficiency: creation of pancreatic islets and bioartificial pancreas.
Authors: Sumi, Shoichiro  kyouindb  KAKEN_id
Author's alias: 角, 昭一郎
Keywords: Diabetes mellitus
Islets of Langerhans
Issue Date: Jan-2011
Publisher: Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer
Journal title: Journal of hepato-biliary-pancreatic sciences
Volume: 18
Issue: 1
Start page: 6
End page: 12
Abstract: Recent advances in pancreas organogenesis have greatly improved the understanding of cell lineage from inner cell mass to fully differentiated β-cells. Based upon such knowledge, insulin-producing cells similar to β-cells to a certain extent have been generated from various cell sources including embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, although fully differentiated cells comparable to β-cells are not yet available. The bioartificial pancreas is a therapeutic approach to enable allo- and xenotransplantation of islets without immune suppression. Among several types of bioartificial pancreases (BAPs), micro-encapsulated porcine islets are already in use in clinical trials and may, perhaps, replace islet transplantation in the near future. Some types of bioartificial pancreas such as macro-encapsulation are also useful for keeping transplanted cells enclosed in case retrieval is necessary. Therefore, early clinical applications of artificially generated β-like cells, especially those from ESCs or iPS cells, will be considered in combination with retrievable BAPs.
Rights: The final publication is available at
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1007/s00534-010-0303-3
PubMed ID: 20589399
Appears in Collections:Journal Articles

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