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Title: Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.
Authors: Sasaki, Naoya
Ishii, Takamichi  kyouindb  KAKEN_id  orcid (unconfirmed)
Kamimura, Ryo
Kajiwara, Masatoshi
Machimoto, Takafumi
Nakatsuji, Norio  kyouindb  KAKEN_id
Suemori, Hirofumi  kyouindb  KAKEN_id
Ikai, Iwao
Yasuchika, Kentaro  kyouindb  KAKEN_id
Uemoto, Shinji  kyouindb  KAKEN_id
Author's alias: 佐々木, 直也
石井, 隆道
Keywords: Cancer stem cell
Pancreatic cancer
Alpha-fetoprotein (AFP)
ATP-binding cassette
Sub-family A (ABC1)
Member 12 (ABCA12)
Issue Date: 28-Sep-2011
Publisher: Elsevier Ireland Ltd.
Journal title: Cancer letters
Volume: 308
Issue: 2
Start page: 152
End page: 161
Abstract: We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance.
Rights: © 2011 Elsevier Ireland Ltd.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.canlet.2011.04.023
PubMed ID: 21616586
Appears in Collections:Journal Articles

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