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j.canlet.2011.04.023.pdf | 1.7 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Sasaki, Naoya | en |
dc.contributor.author | Ishii, Takamichi | en |
dc.contributor.author | Kamimura, Ryo | en |
dc.contributor.author | Kajiwara, Masatoshi | en |
dc.contributor.author | Machimoto, Takafumi | en |
dc.contributor.author | Nakatsuji, Norio | en |
dc.contributor.author | Suemori, Hirofumi | en |
dc.contributor.author | Ikai, Iwao | en |
dc.contributor.author | Yasuchika, Kentaro | en |
dc.contributor.author | Uemoto, Shinji | en |
dc.contributor.alternative | 佐々木, 直也 | ja |
dc.contributor.alternative | 石井, 隆道 | ja |
dc.date.accessioned | 2011-08-25T00:42:01Z | - |
dc.date.available | 2011-08-25T00:42:01Z | - |
dc.date.issued | 2011-09-28 | - |
dc.identifier.issn | 0304-3835 | - |
dc.identifier.uri | http://hdl.handle.net/2433/145219 | - |
dc.description.abstract | We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ireland Ltd. | en |
dc.rights | © 2011 Elsevier Ireland Ltd. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Cancer stem cell | en |
dc.subject | Pancreatic cancer | en |
dc.subject | Alpha-fetoprotein (AFP) | en |
dc.subject | ATP-binding cassette | en |
dc.subject | Sub-family A (ABC1) | en |
dc.subject | Member 12 (ABCA12) | en |
dc.title | Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00598513 | - |
dc.identifier.jtitle | Cancer letters | en |
dc.identifier.volume | 308 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 152 | - |
dc.identifier.epage | 161 | - |
dc.relation.doi | 10.1016/j.canlet.2011.04.023 | - |
dc.textversion | author | - |
dc.identifier.pmid | 21616586 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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