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| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.canlet.2011.04.023.pdf | 1.7 MB | Adobe PDF | 見る/開く |
| タイトル: | Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics. |
| 著者: | Sasaki, Naoya Ishii, Takamichi    https://orcid.org/0000-0002-7461-9653 (unconfirmed)Kamimura, Ryo Kajiwara, Masatoshi Machimoto, Takafumi Nakatsuji, Norio Suemori, Hirofumi https://orcid.org/0000-0002-3565-3111 (unconfirmed)Ikai, Iwao Yasuchika, Kentaro Uemoto, Shinji |
| 著者名の別形: | 佐々木, 直也 石井, 隆道 |
| キーワード: | Cancer stem cell Pancreatic cancer Alpha-fetoprotein (AFP) ATP-binding cassette Sub-family A (ABC1) Member 12 (ABCA12) |
| 発行日: | 28-Sep-2011 |
| 出版者: | Elsevier Ireland Ltd. |
| 誌名: | Cancer letters |
| 巻: | 308 |
| 号: | 2 |
| 開始ページ: | 152 |
| 終了ページ: | 161 |
| 抄録: | We aimed to demonstrate the existence of cancer stem cells in human pancreatic cancer, and to clarify that they are alpha-fetoprotein (AFP) producing cells. Six cell lines derived from human pancreatic cancers were examined, and AsPC-1 and PANC-1 were noted to express AFP. Single cell culture assays and xenotransplantation revealed that the AFP-producing cells had the capacity for self-renewal and differentiation, and that these cells were tumorigenic. Furthermore, they were resistant to anti-cancer agents. The ABCA12 transporter was expressed in the AFP-producing cells at a level more than twice as high as that in the non-AFP-producing cells. The AFP-producing cells were shown to be putative pancreatic cancer stem cells. Furthermore, the expression of ABCA12 appears to be associated with drug resistance. |
| 著作権等: | © 2011 Elsevier Ireland Ltd. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
| URI: | http://hdl.handle.net/2433/145219 |
| DOI(出版社版): | 10.1016/j.canlet.2011.04.023 |
| PubMed ID: | 21616586 |
| 出現コレクション: | 学術雑誌掲載論文等 |
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