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dc.contributor.author | Ishizaki, Natsumi | en |
dc.contributor.author | Kotani, Megumi | en |
dc.contributor.author | Funaba, Masayuki | en |
dc.contributor.author | Matsui, Tohru | en |
dc.contributor.alternative | 舟場, 正幸 | ja |
dc.contributor.alternative | 松井, 徹 | ja |
dc.date.accessioned | 2011-11-17T07:53:32Z | - |
dc.date.available | 2011-11-17T07:53:32Z | - |
dc.date.issued | 2011-10 | - |
dc.identifier.issn | 0007-1145 | - |
dc.identifier.uri | http://hdl.handle.net/2433/149857 | - |
dc.description.abstract | Mg deficiency accelerates Fe accumulation in the liver, which may induce various metabolic disturbances. In the present study, we examined the gene expression of Hepcidin, a peptide hormone produced in the liver to regulate intestinal Fe absorption negatively, in Mg-deficient rats. Although liver Fe concentration was significantly higher in rats fed an Mg-deficient diet for 4 weeks than in rats fed a control diet, Hepcidin expression in the liver was comparable between the dietary groups. Previous studies revealed that Fe overload up-regulated Hepcidin expression through transcriptional activation by Fe-induced bone morphogenetic protein (Bmp) 6, a growth/differentiation factor belonging to the transforming growth factor-β family, in the liver. Mg deficiency up-regulated the expression of Bmp6 but did not affect the expression of inhibition of DNA binding 1, a sensitive Bmp-responsive gene. In addition, the expression of Bmp receptors such as activin receptor-like kinase 2 (Alk2), activin receptor type IIA (Actr2a), activin receptor type IIB (Actr2b) and Bmp type II receptor (Bmpr2) was lower in the liver of Mg-deficient rats than in that of control rats. The present study indicates that accumulation of hepatic Fe by Mg deficiency is a stimulant inducing Bmp6 expression but not Hepcidin expression by blunting Bmp signalling possibly resulting from down-regulation of the receptor expression. Unresponsive Hepcidin expression may have a role in Mg deficiency-induced changes related to increased liver Fe. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Cambridge University Press | en |
dc.rights | Copyright © The Authors 2011. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Magnesium deficiency | en |
dc.subject | Hepcidin | en |
dc.subject | Liver iron content | en |
dc.subject | Bone morphogenetic protein | en |
dc.title | Hepcidin expression in the liver of rats fed a magnesium-deficient diet. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00574708 | - |
dc.identifier.jtitle | The British journal of nutrition | en |
dc.identifier.volume | 106 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 1169 | - |
dc.identifier.epage | 1172 | - |
dc.relation.doi | 10.1017/S0007114511001553 | - |
dc.textversion | author | - |
dc.identifier.pmid | 21736832 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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