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dc.contributor.author | Yoshidome, Takashi | en |
dc.contributor.alternative | 吉留, 崇 | ja |
dc.date.accessioned | 2012-01-06T07:04:30Z | - |
dc.date.available | 2012-01-06T07:04:30Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1349-2942 | - |
dc.identifier.uri | http://hdl.handle.net/2433/152166 | - |
dc.description.abstract | We briefly review our theoretical study on the rotation scheme of F1-ATPase. In the scheme, the key factor is the water entropy which has been shown to drive a variety of self-assembly processes in biological systems. We decompose the crystal structure of F1-ATPase into three sub-complexes each of which is composed of the γ subunit, one of the β subunits, and two α subunits adjacent to them. The βE, βTP, and βDP subunits are involved in the sub-complexes I, II, and III, respectively. We calculate the hydration entropy of each sub-complex using a hybrid of the integral equation theory for molecular liquids and the morphometric approach. It is found that the absolute value of the hydration entropy follows the order, sub-complex I > sub-complex II > sub-complex III. Moreover, the differences are quite large, which manifests highly asymmetrical packing of F1-ATPase. In our picture, this asymmetrical packing plays crucially important roles in the rotation of the γ subunit. We discuss how the rotation is induced by the water-entropy effect coupled with such chemical processes as ATP binding, ATP hydrolysis, and release of the products. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Biophysical Society of Japan | en |
dc.rights | (c) 2011 THE BIOPHYSICAL SOCIETY OF JAPAN | en |
dc.subject | Asymmetric packing | en |
dc.subject | water | en |
dc.subject | hydration entropy | en |
dc.subject | integral equation theory | en |
dc.subject | morphometric approach | en |
dc.title | Importance of water entropy in rotation mechanism of F1-ATPase | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | BIOPHYSICS | en |
dc.identifier.volume | 7 | - |
dc.identifier.spage | 113 | - |
dc.identifier.epage | 122 | - |
dc.relation.doi | 10.2142/biophysics.7.113 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 27857599 | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 1349-2942 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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