このアイテムのアクセス数: 967

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
journal.pone.0031317.pdf563.53 kBAdobe PDF見る/開く
タイトル: Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice
著者: Kim, Young-il
Hirai, Shizuka
Goto, Tsuyoshi  kyouindb  KAKEN_id
Ohyane, Chie
Takahashi, Haruya  kyouindb  KAKEN_id
Tsugane, Taneaki
Konishi, Chiaki
Fujii, Takashi
Inai, Shuji
Iijima, Yoko
Aoki, Koh
Shibata, Daisuke
Takahashi, Nobuyuki
Kawada, Teruo  kyouindb  KAKEN_id
著者名の別形: 河田, 照雄
金, 英一
発行日: 9-Feb-2012
出版者: Public Library of Science
引用: Kim Y-i, Hirai S, Goto T, Ohyane C, Takahashi H, et al. (2012) Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice. PLoS ONE 7(2): e31317. doi:10.1371/journal.pone.0031317
誌名: PLoS ONE
巻: 7
号: 2
開始ページ: e31317
抄録: Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10,12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9,11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis.
記述: トマトから脂肪肝、血中中性脂肪改善に有効な健康成分を発見:効果を肥満マウスで確認. 京都大学プレスリリース. 2012-02-10.
著作権等: © 2012 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URL: http://dx.plos.org/10.1371/journal.pone.0031317
URI: http://hdl.handle.net/2433/152546
DOI(出版社版): 10.1371/journal.pone.0031317
関連リンク: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/120210_1.htm
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。