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タイトル: | Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice |
著者: | Kim, Young-il Hirai, Shizuka Goto, Tsuyoshi ![]() ![]() ![]() Ohyane, Chie Takahashi, Haruya ![]() ![]() ![]() Tsugane, Taneaki Konishi, Chiaki Fujii, Takashi Inai, Shuji Iijima, Yoko Aoki, Koh Shibata, Daisuke Takahashi, Nobuyuki Kawada, Teruo ![]() |
著者名の別形: | 河田, 照雄 金, 英一 |
発行日: | 9-Feb-2012 |
出版者: | Public Library of Science |
引用: | Kim Y-i, Hirai S, Goto T, Ohyane C, Takahashi H, et al. (2012) Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice. PLoS ONE 7(2): e31317. doi:10.1371/journal.pone.0031317 |
誌名: | PLoS ONE |
巻: | 7 |
号: | 2 |
開始ページ: | e31317 |
抄録: | Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10, 12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9, 11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis. |
記述: | トマトから脂肪肝、血中中性脂肪改善に有効な健康成分を発見:効果を肥満マウスで確認. 京都大学プレスリリース. 2012-02-10. |
著作権等: | © 2012 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/152546 |
DOI(出版社版): | 10.1371/journal.pone.0031317 |
PubMed ID: | 22347463 |
関連リンク: | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2011/120210_1.htm http://dx.plos.org/10.1371/journal.pone.0031317 |
出現コレクション: | 学術雑誌掲載論文等 |
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