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Title: Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice
Authors: Kim, Young-il
Hirai, Shizuka
Goto, Tsuyoshi  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1283-147X (unconfirmed)
Ohyane, Chie
Takahashi, Haruya  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-3182-2894 (unconfirmed)
Tsugane, Taneaki
Konishi, Chiaki
Fujii, Takashi
Inai, Shuji
Iijima, Yoko
Aoki, Koh
Shibata, Daisuke
Takahashi, Nobuyuki
Kawada, Teruo  kyouindb  KAKEN_id
Author's alias: 河田, 照雄
金, 英一
Issue Date: 9-Feb-2012
Publisher: Public Library of Science
Citation: Kim Y-i, Hirai S, Goto T, Ohyane C, Takahashi H, et al. (2012) Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice. PLoS ONE 7(2): e31317. doi:10.1371/journal.pone.0031317
Journal title: PLoS ONE
Volume: 7
Issue: 2
Start page: e31317
Abstract: Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10, 12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9, 11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis.
Description: トマトから脂肪肝、血中中性脂肪改善に有効な健康成分を発見:効果を肥満マウスで確認. 京都大学プレスリリース. 2012-02-10.
Rights: © 2012 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
URI: http://hdl.handle.net/2433/152546
DOI(Published Version): 10.1371/journal.pone.0031317
PubMed ID: 22347463
Related Link: http://dx.plos.org/10.1371/journal.pone.0031317
https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2011/120210_1.htm
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