ダウンロード数: 612
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
092050610X501713.pdf | 556.05 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Takafuji, Yoshimasa | en |
dc.contributor.author | Jo, Jun-Ichiro | en |
dc.contributor.author | Tabata, Yasuhiko | en |
dc.contributor.alternative | 田畑, 泰彦 | ja |
dc.date.accessioned | 2012-06-15T00:46:52Z | - |
dc.date.available | 2012-06-15T00:46:52Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | http://hdl.handle.net/2433/156425 | - |
dc.description.abstract | A simple modification of a DNA aptamer with poly(ethylene glycol) (PEG) based on metal coordination was developed. N, N-bis(carboxymethyl)-L-lysine (NTA) of a metal chelate residue was chemically introduced to one terminus of PEG. The NTA-introduced PEG (PEG-NTA) chelated Cu(2+) ions form a Cu(2+)-chelated PEG (PEG-Cu). When PEG-Cu was mixed with a DNA aptamer of anti-tumor activity (AS1411) in aqueous solution, a complex of PEG-Cu and AS1411 based on metal coordination was formed. The complex inhibited in vitro tumor growth in a dose-dependent manner. A body distribution study with tumor-bearing mice revealed that PEG-Cu-AS1411 complexes injected intravenously had a significant longer lifetime in the blood circulation and 1.5-2.0-fold higher accumulation in the tumor tissue than free AS1411. Intravenous injection of complexes suppressed the in vivo growth of tumor mass to a significantly greater extent compared with that of free AS1411. The Cu(2+)-coordinated PEG modification is a simple and promising method to enhance accumulation of the aptamer in the tumor, resulting in the augmented anti-tumor effect. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | VSP, an imprint of Brill | en |
dc.rights | Copyright 2011 Brill. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | DNA APTAMER | en |
dc.subject | POLY(ETHYLENE GLYCOL) | en |
dc.subject | METAL COORDINATION | en |
dc.subject | TUMOR TARGETING | en |
dc.subject | ANTI-TUMOR EFFECT | en |
dc.title | Simple PEG Modification of DNA Aptamer Based on Copper Ion Coordination for Tumor Targeting. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10731799 | - |
dc.identifier.jtitle | Journal of biomaterials science. Polymer edition | en |
dc.identifier.volume | 22 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 1179 | - |
dc.identifier.epage | 1198 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20615331 | - |
dc.relation.url | http://www.ingentaconnect.com/content/vsp/bsp/2011/00000022/00000009/art00005 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。